- Colorpoint
The exact name of the colorpoint pattern depends on the actual color, so there are seal points (dark brown), chocolate points (warm lighter brown), blue points (dark gray), lilac or frost points (silvery gray-pink), red or flame points (orange), and tortie (tortoiseshell mottling) points, among others.
This pattern is the result of a temperature sensitive mutation in one of the enzymes in the metabolic pathway from tyrosine to pigment, such as melanin; thus, little or no pigment is produced except in the extremities or points where the skin is slightly cooler.
For this reason, colorpointed cats tend to darken with age as bodily temperature drops; also, the fur over a significant injury may sometimes darken or lighten as a result of temperature change. The tyrosine pathway also produces neurotransmitters, thus mutations in the early parts of that pathway may affect not only pigment, but also neurological development.
This results in a higher frequency of cross-eyes among colorpointed cats, as well as the high frequency of cross-eyes in white tigers.
White cats
True albinism (a mutation of the tyrosinase gene) is quite rare in cats. Much more common is the appearance of white coat color due to a lack of melanocytes in the skin. A higher frequency of deafness in white cats is due to a reduction in the population and survival of melanoblast stem cells, which in addition to creating pigment producing cells, develop into a variety of neurological cell types. White cats with one or two blue eyes have a particularly high likelihood of being deaf.
The bottom eighth of each hair is white or creamy-white, with the rest of the hair being a solid color. Genetically this color is a non-agouti cat with the dominant inhibitor gene; a non-agouti version of the silver tabby. Smoke cats will look solid colored until they move, when the white undercoat becomes apparent. It is mostly found in pedigreed cats (especially longhair breeds) but also present in some domestic longhaired cats.
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