In captivity, indoor cats typically live 14 to 20 years, although the oldest known cat, Creme Puff, lived to age 38. Some say that domesticated cats tend to live longer if they are not permitted to go outdoors (reducing the risk of injury from fights or accidents and exposure to diseases).
However, this is not always necessarily true, because a cat kept indoors is more inclined to have a shortened life due to obesity (sometimes leading to heart problems and diabetes) and lack of exercise. Having a cat be neutered, however, is almost universally regarded as a health benefit.
Some benefits of neutering are that castrated males cannot develop testicular cancer, spayed females cannot develop uterine or ovarian cancer, and both have a reduced risk of mammary cancer. The lifespan of feral cats is hard to determine accurately, although one study reported a median age of 4.7 years, with a range between 0 to 10 years.
Cats can suffer from a wide range of health problems, including infectious diseases, parasites, injuries and chronic disease. Vaccinations are available for many of these diseases, and domestic cats are regularly given treatments to eliminate parasites such as worms and fleas.
In addition to obvious dangers such as rodenticides, insecticides and weed killers, cats may be poisoned by many chemicals that are usually considered safe. This is because their livers are less effective at some forms of detoxification than those of other animals, including humans and dogs. Some of the most common causes of poisoning in cats are antifreeze and rodent baits.
It has also been suggested that cats may be particularly sensitive to environmental pollutants. When a cat has a sudden or prolonged serious illness without any obvious cause, it is therefore possible that it has been exposed to a toxin. Human medicines should never be given to cats. For example, the painkiller paracetamol (also called acetaminophen), sold under brand names such as Tylenol and Panadol is extremely toxic to cats: even very small doses can be fatal and need immediate treatment.
Even aspirin, which is sometimes used to treat arthritis in cats, is much more toxic to them than to humans and must be administered cautiously. Similarly, application of minoxidil (Rogaine) to the skin of cats, either accidentally or by well-meaning owners attempting to counter loss of fur, has sometimes been fatal.
Essential oils can be toxic to cats and there have been reported cases of serious illnesses caused by tea tree oil, and tea tree oil-based flea treatments and shampoos. Other common household substances that should be used with caution around cats include mothballs and other naphthalene products.
Phenol-based products are often used for cleaning and disinfecting near cats' feeding areas or litter boxes: such as Pine-Sol, Dettol (Lysol) or hexachlorophene, but these can sometimes be fatal. Ethylene glycol, often used as an automotive antifreeze, is particularly appealing to cats, and as little as a teaspoonful can be fatal.
Some human foods are toxic to cats; for example theobromine in chocolate can cause theobromine poisoning, although few cats will eat chocolate. Large amounts of onions or garlic are also poisonous to cats. Many houseplants are also dangerous, such as Philodendron species and the leaves of the Easter Lily, which can cause permanent and life-threatening kidney damage.